2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

Related Products

PDF 3.24 MB

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

E3 Ligase Ligand-Linker Conjugates Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130798
    (S,R,S)-AHPC-amido-C5-acid 2162120-87-6 99.58%
    (S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180).
    (S,R,S)-AHPC-amido-C5-acid
  • HY-134982
    Thalidomide-piperazine-Boc 2222114-64-7 98.82%
    Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC.
    Thalidomide-piperazine-Boc
  • HY-130849
    (S,R,S)-AHPC-Me-C5-COOH 2229976-21-8
    (S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604).
    (S,R,S)-AHPC-Me-C5-COOH
  • HY-130521
    Pomalidomide-amido-PEG3-C2-NH2 2328070-52-4 99.55%
    Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
    Pomalidomide-amido-PEG3-C2-NH2
  • HY-122694A
    Thalidomide-O-amido-PEG-C2-NH2 hydrochloride 2204226-02-6 98.10%
    Thalidomide-O-amido-PEG-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
    Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
  • HY-W584518
    Thalidomide-5-O-CH2-COOH 2467425-53-0
    Thalidomide-5-O-CH2-COOH is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-5-O-CH2-COOH acts as a ligand for Cereblon to recruit CRBN protein. Thalidomide-5-O-CH2-COOH is a key intermediate in the synthesis of PROTAC molecules designed based on CRBN.
    Thalidomide-5-O-CH2-COOH
  • HY-W580022
    Pomalidomide-5'-PEG8-C2-COOH 2138440-78-3 98.21%
    Pomalidomide-5'-PEG8-C2-COOH is an E3 Ligase Ligand-Linker Conjugates, consisting of Pomalidomide (HY-10984) and a linker. Pomalidomide-5'-PEG8-C2-COOH can be used for synthesis of PROTACs.
    Pomalidomide-5'-PEG8-C2-COOH
  • HY-103606
    (S,R,S)-AHPC-PEG6-C4-Cl 1835705-59-3
    (S,R,S)-AHPC-PEG6-C4-Cl is a conjugate of ligands for E3 and 25-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG6-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
    (S,R,S)-AHPC-PEG6-C4-Cl
  • HY-103611
    Thalidomide-O-amido-PEG3-C2-NH2 TFA 1957236-21-3 99.55%
    Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
    Thalidomide-O-amido-PEG3-C2-NH2 TFA
  • HY-103615
    Thalidomide-O-amido-C4-N3 2098488-36-7 98.36%
    Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Thalidomide-O-amido-C4-N3
  • HY-136162
    Thalidomide-4-O-C2-NH2 hydrochloride 2341840-99-9 99.37%
    Thalidomide-4-O-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-4-O-C2-NH2 hydrochloride
  • HY-140942
    Biotin-PEG6-Thalidomide 2144775-48-2 98.51%
    Biotin-PEG6-Thalidomide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG6-Thalidomide
  • HY-163167
    VH 032 amide-alkylC5-azide 2821804-11-7 98.32%
    VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand.
    VH 032 amide-alkylC5-azide
  • HY-150006
    Pomalidomide-C2-acid 2225940-46-3 99.78%
    Pomalidomide-C2-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
    Pomalidomide-C2-acid
  • HY-112618A
    Thalidomide-O-amido-C6-NH2 TFA 1950635-14-9 99.82%
    Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
    Thalidomide-O-amido-C6-NH2 TFA
  • HY-130948B
    Thalidomide-4-O-C4-NH2 hydrochloride 2376990-29-1 99.35%
    Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-4-O-C4-NH2 hydrochloride
  • HY-128716A
    Pomalidomide-PEG3-C2-NH2 TFA 2414913-97-4 99.0%
    Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs.
    Pomalidomide-PEG3-C2-NH2 TFA
  • HY-131159
    Thalidomide-O-C8-Boc 2225148-52-5
    Thalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-O-C8-Boc
  • HY-136184
    (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride 2376990-26-8 99.01%
    (S,R,S)-AHPC-phenol-C4-NH2 (VH032-phenol-C4-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology.
    (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride
  • HY-114176B
    (S,R,S)-AHPC-C4-NH2 dihydrochloride 2341796-78-7
    (S,R,S)-AHPC-C4-NH2 dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC.
    (S,R,S)-AHPC-C4-NH2 dihydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
E3 Ligase Ligand-Linker Conjugates Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.